Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10014202
Fusion event
HBV-LURAP1L integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2401
Orient
+
Integrated sequence
CCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAA| |GGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTT
Host Sequence
Chromosome
chr9
Cytoband
p23
Reference genome
Start
End
12812722/12812723 (Hg38)
Orient
+
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-503-5p ; hsa-mir-1253 ; hsa-mir-3185 ; hsa-mir-4434 ; hsa-mir-4516 ; hsa-mir-4524a-5p ; hsa-mir-4524b-5p ; hsa-mir-5703 ; hsa-mir-7846-3p ; hsa-mir-1228-3p ; hsa-mir-646 ; hsa-mir-6882-5p ; hsa-mir-497-5p ; hsa-mir-16-5p ; hsa-mir-6838-5p ; hsa-mir-195-5p ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-424-5p ; hsa-mir-300 ; hsa-mir-381-3p
Nearest miRNA
hsa-mir-101-2/Upstream/6804819; hsa-let-7a-1/Downstream/5760583;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/36909, chr9-CpG: 144/Downstream/465590
Upstream sequence
AATACCAATATCCAGAAATTGGGGAAGTTTATGACACACAGTCAGACCCACATTTCATGGTCAATTTTTAAATCAACAAATGGCCATAATGAAGACAATA
Downstream sequence
TCCTCAACAATCTTCAAATGCATTGCTGAACAACTCTGCATTATAAAGCCTACTGTTTATAACAGTGGCCTCTTATTTTAGAAATATAGCCATCAAAAAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.