Basic Information
VIS ID
TVIS10014204
Fusion event
HBV-chr9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2424
Orient
-
Integrated sequence
AACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGA| |AGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCT
Host Sequence
Chromosome
chr9
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
24083452/24083454 (Hg38)
End
24083452/24083454 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA9C
Nearest miRNA
hsa-mir-101-2/Upstream/2571269; hsa-let-7a-1/Downstream/4780172;
Nearest TSS
ENST00000422679/Upstream/185400; ENST00000602614/Downstream/462222;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/231930, chr9-CpG: 111/Downstream/1594042
Nearby gene
ELAVL2(-257389) ; TUSC1(+1592935) ;
Nearest cancer related gene
TUSC1(TSG, +1592935) ;
Upstream sequence
gtacaataccaaacctctttgaccttgtgttactcatacccatccacatCCAACTCAGGAAAATCACACTTCTAAGTAGTCAAGCTGTTTGCAGCCCTTG
Downstream sequence
AAGCTTAGAGTTTTAACAGTTTATGCTCCTTATAGATAGATGACATAACCTCTACAAACCAGAATTTCACCTAAAGATGGCACCCTCCTTTGGAAAAACA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate