Basic Information
VIS ID
TVIS10014208
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1895
Orient
+
Integrated sequence
TTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCT| |TTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTA
Host Sequence
Chromosome
chrX
Cytoband
q27.2
Reference genome
GRCh37/hg19
Start
140799384/141711228 (Hg38)
End
140799384/141711228 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRAXD
Nearest miRNA
hsa-let-7f-2/Upstream/784997; hsa-mir-105-1/Downstream/4281522;
Nearest TSS
ENST00000429181/Upstream/12489; ENST00000483584/Downstream/127088;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/534008, chrX-CpG: 130/Downstream/1922366
Nearby gene
SPANXD(-12729) ; MAGEC3(+126718) ;
Upstream sequence
TTGAACACATCCAGCCTTTTTGTGTGTTGTGATTTTTCATTAAATACTAGCAAAATTGTCTTCTCCATGGATAATTCATAGAGTCAATGTCAATGGCCTT
Downstream sequence
ggtgcatgcttgtaatcccagctacttgggaggctgaggcaggagaatcgcttgaacccaggaggtggaggttgcagtgaactgagatcatgccactgca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate