VISDB Viral Integration Site DataBase

VIS ID

TVIS10014212

Fusion event

HBV-DIAPH2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

1923

Orient

+

Integrated sequence

TTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAA| |GAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAG

Chromosome

chrX

Cytoband

q21.33

Reference genome

Start

End

96705807/97450808 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-10b-5p ; hsa-mir-17-3p ; hsa-mir-4520-3p ; hsa-mir-4520-2-3p ; hsa-mir-20a-5p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-4473 ; hsa-mir-4671-3p ; hsa-mir-4778-3p ; hsa-mir-520f-3p ; hsa-mir-302c-3p ; hsa-mir-512-3p ; hsa-mir-641 ; hsa-mir-3617-5p

Nearest miRNA

hsa-let-7f-2/Upstream/2387582; hsa-mir-105-1/Downstream/9189006;

Nearest TSS

Nearest CpG islands

None/Target, chrX-CpG: 62/Upstream/765441, chrX-CpG: 23/Downstream/2488528

Upstream sequence

Tgttgtacatagttttggatacatgtatatatttggatacatatacacaatgtgtaatgatcaagtcagggtaatcaggatacccatcacttcaaatatt

Downstream sequence

CCTTCATTAAGATGTACTGTCCATTTTGAATGACAGCTTTAAGTCACAGGATAAGCCTCCTATACAATGGGCTACTTTTTTTTTTTTTTTTAAAGGAAGA