Basic Information
VIS ID
TVIS10014218
Fusion event
HBV-LINC01036 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
28
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGC| |AAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTT
Host Sequence
Chromosome
chr1
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
187316205/187347073 (Hg38)
End
187316205/187347073 (Hg38)
Orient
-
Location type
ncRNA_intronic
Fragile sites / regions
FRA1K
Target gene
LINC01036
Nearest miRNA
hsa-mir-101-1/Upstream/6908683; hsa-mir-1182/Downstream/5369255;
Nearest TSS
ENST00000473358/Upstream/39679; ENST00000614505/Downstream/294153;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/666124, chr1-CpG: 56/Downstream/5461429
Upstream sequence
gttctcgttggtttcaaagaacatctttatttctgccttcatttcgttatgtacccagtagtcattcaggagcaggttgttcagtttccatgtagttgag
Downstream sequence
tggctttgagtgagattcttaatcctgagttctagtttgattgcactgtggtctgagagatagtttgttataatttctgttcttttacatttgctgagga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate