Basic Information
VIS ID
TVIS10014220
Fusion event
HBV-LOC100216488 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
118
Orient
+
Integrated sequence
CAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTAT| |CGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTT
Host Sequence
Chromosome
chr1
Cytoband
q44
Reference genome
GRCh37/hg19
Start
248333160/248169858 (Hg38)
End
248333160/248169858 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1I
Target gene
LOC100216488
Nearest miRNA
hsa-mir-101-1/Upstream/967798; hsa-mir-3124/Downstream/656519;
Nearest TSS
ENST00000473358/Upstream/24710; ENST00000359682/Downstream/4963;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/232434, chr1-CpG: 49/Downstream/521871
Nearby gene
OR2M5(-23772) ; OR2M2(+10128) ;
Upstream sequence
tgtgtctttgttctcgttggtttcaaagaacatctttatttctgccttcatttcgttatgtacccagtagtcattcaggagcaggttgttcagtttccat
Downstream sequence
gtagttgagtggctttgagtgagattcttaatcctgagttctagtttgattgcactgtggtctgagagatagtttgttataatttctgttcttttacatt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate