Basic Information
VIS ID
TVIS10014221
Fusion event
HBV-LOC105378641 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
27
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTG| |CAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCT
Host Sequence
Chromosome
chr1
Cytoband
p34.3
Reference genome
GRCh37/hg19
Start
35034978/34569377 (Hg38)
End
35034978/34569377 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105378641
Nearest miRNA
hsa-mir-12136/Upstream/1236885; hsa-mir-101-1/Downstream/100222;
Nearest TSS
ENST00000473358/Upstream/391707; ENST00000338513/Downstream/185670;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/391954, chr1-CpG: 22/Downstream/192050
Nearby gene
C1orf94(-350247) ; GJB5(+185670) ;
Upstream sequence
tctttgttctcgttggtttcaaagaacatctttatttctgccttcattttgttatgtacccagtagtcattcaggagcaggttgttcagtttccatgtag
Downstream sequence
ttgagtggctttgagtgagattcttaatcctgagttctagtttgattgcactgtggtctgagagatagtttgttataatttctgttcttttacatttgct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate