Basic Information
VIS ID
TVIS10014229
Fusion event
HBV-HECTD2-AS1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
33
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGAT| |CCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGA
Host Sequence
Chromosome
chr10
Cytoband
q23.32
Reference genome
GRCh37/hg19
Start
93265697/91505940 (Hg38)
End
93265697/91505940 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA10D
Target gene
HECTD2-AS1
Nearest miRNA
hsa-mir-107/Upstream/1913113; hsa-mir-1287/Downstream/4558375;
Nearest TSS
ENST00000439456/Upstream/21832; ENST00000371627/Downstream/127114;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/95124, chr10-CpG: 49/Downstream/126970
Upstream sequence
cacctattccaaaattgaccacatacttggaagtaaagctctcctcagcaaatgtaaaagaacagacactataacaaactatctctcagaccacagtgca
Downstream sequence
atcaaactagaactcaggattaagaatctcactcaaagccactcaactacatggaaactgaacaacctgctcctgaatgactactgggtacataacgaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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