Basic Information
VIS ID
TVIS10014234
Fusion event
HBV-TIGAR integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
53
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTA| |TTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTG
Host Sequence
Chromosome
chr12
Cytoband
p13.32
Reference genome
GRCh37/hg19
Start
4452746/4343580 (Hg38)
End
4452746/4343580 (Hg38)
Orient
+
Location type
Intronic
Target gene
TIGAR
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-26b-5p ; hsa-mir-193b-3p ; hsa-mir-4698 ; hsa-mir-6516-5p ; hsa-mir-455-3p ; hsa-mir-7847-3p ; hsa-mir-6880-5p ; hsa-mir-6851-5p ; hsa-mir-3689d ; hsa-mir-6499-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-6134 ; hsa-mir-4740-3p ; hsa-mir-122-3p ; hsa-mir-1273e ; hsa-mir-219b-3p ; hsa-mir-302f ; hsa-mir-629-3p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-627-3p ; hsa-mir-3925-3p ; hsa-mir-6832-3p ; hsa-mir-766-3p ; hsa-mir-8063 ; hsa-mir-605-5p ; hsa-mir-4668-3p ; hsa-mir-6866-3p ; hsa-mir-188-5p ; hsa-mir-204-5p ; hsa-mir-211-5p ; hsa-mir-548s ; hsa-mir-4642 ; hsa-mir-3926 ; hsa-mir-3190-5p ; hsa-mir-6870-3p ; hsa-mir-1304-3p ; hsa-mir-6500-3p ; hsa-mir-3614-5p ; hsa-mir-1285-5p ; hsa-mir-193a-3p ; hsa-mir-5197-5p ; hsa-mir-1247-3p ; hsa-mir-1306-5p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-4279 ; hsa-mir-4532 ; hsa-mir-4714-3p ; hsa-mir-4722-3p ; hsa-mir-498 ; hsa-mir-6727-3p ; hsa-mir-6747-3p ; hsa-mir-6807-5p
Nearest miRNA
hsa-mir-3649/Upstream/2683200; hsa-let-7i/Downstream/2620119;
Nearest TSS
ENST00000382841/Upstream/8047; ENST00000538817/Downstream/36148;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/18762, chr12-CpG: 38/Downstream/26776
Upstream sequence
aagtaaagcattcctcagcaaatgcaaaagaacagaaattataacaaactatctctcagaccatagtgcaatcaaactagaactcagaattaagaaactc
Downstream sequence
aaagccactcaactacatggaaactgaacaacctgctcctgaatgactactgggtacataacgaaatgaaggcagaaataaagatgttctttgaaaccaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate