Basic Information
VIS ID
TVIS10014239
Fusion event
HBV-chr14 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
11
Orient
+
Integrated sequence
AATTCCACAAC| |CTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCT
Host Sequence
Chromosome
chr14
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
48659134/48189931 (Hg38)
End
48659134/48189931 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-208a/Upstream/428827; hsa-mir-1185-1/Downstream/1776468;
Nearest TSS
ENST00000550708/Upstream/394839; ENST00000557531/Downstream/301836;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/513545, chr14-CpG: 30/Downstream/1396001
Nearby gene
LINC00648(-394917) ; RPS29(+1384256) ;
Upstream sequence
tgctcctgaatgactactgggtacataacgaaatgaaggcagaaataaagatgttctttgaaaccaacgagaacaaagacaccacataccagaatctctg
Downstream sequence
ggacgcattcaaagcagtgtgtagagggaaatttatagcactaaatgcctacaagagaaagcgggaaagatccaaaattgacaccctaacatcacaatta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate