Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10014240
Fusion event
HBV-ADAM20 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
Polymerase|large S protein|middle S protein|
Start
146
Orient
+
Integrated sequence
GCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCC| |TGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAG
Host Sequence
Chromosome
chr14
Cytoband
q24.2
Reference genome
Start
End
71016819/70550102 (Hg38)
Orient
+
Location type
Intronic
Target gene
Nearest miRNA
hsa-mir-208a/Upstream/3108172; hsa-mir-1185-1/Downstream/1966718;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/190239, chr14-CpG: 135/Downstream/91189
Upstream sequence
actcaaagccactcaactacatggaaactgaacaacctgctcctgaatgactactgggtacataacgaaatgaaggcagaaataaagatgttctttgaaa
Downstream sequence
ccaacgagaacaaagacaccacataccagaatctctgggacgcattcaaagcagtgtgtagagggaaatttatagcactaaatgcctacaagagaaagca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.