Basic Information
VIS ID
TVIS10014242
Fusion event
HBV-chr14 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
2
Orient
+
Integrated sequence
AA| |TTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACT
Host Sequence
Chromosome
chr14
Cytoband
q31.2
Reference genome
GRCh37/hg19
Start
84108317/83641973 (Hg38)
End
84108317/83641973 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1260a/Upstream/6375683; hsa-mir-1185-1/Downstream/10306253;
Nearest TSS
ENST00000550708/Upstream/602371; ENST00000554753/Downstream/273077;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/2107883, chr14-CpG: 45/Downstream/1888177
Nearby gene
LINC00911(+1751906) ;
Upstream sequence
cagcaccacaccacacctattccaaaattgaccacatagtgggaagtaaagctctcctcagcaaatgtaaaagaacagaaattataacaaactatctctc
Downstream sequence
agaccacagtgcaatcaaactagaactcaggattaagaatctcactcaaaaccgctcaactacatggaaactgaacaacctgctcctgaatgactactgg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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