Basic Information
VIS ID
TVIS10014247
Fusion event
HBV-chr18 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1750
Orient
+
Integrated sequence
CTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAG| |GAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTG
Host Sequence
Chromosome
chr18
Cytoband
p11.32
Reference genome
GRCh37/hg19
Start
105574/105574 (Hg38)
End
105574/105574 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1-2/Downstream/6682;
Nearest TSS
ENST00000575820/Upstream/32029; ENST00000580410/Downstream/52809;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/29547, chr18-CpG: 21/Downstream/6735
Nearby gene
LOC102723376(-89644) ; ROCK1P1(+3491) ;
Upstream sequence
ccgaacccgaatccaaacttgaacctgaaccctaagccttaccctaagcctaagcctaacccctaaccctaaccctaaccctaaacctaatgctcaccct
Downstream sequence
aaccctaaccctcaccctcaccctgaccctcaccctcaccctgaccctcaccctgaccctcaccctgaccctcaccctaaccctaaccctcaccctCGCc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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