Basic Information
VIS ID
TVIS10014250
Fusion event
HBV-chr18 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
53
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTA| |TTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTG
Host Sequence
Chromosome
chr18
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
32788412/35208448 (Hg38)
End
32788412/35208448 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA18A
Nearest miRNA
hsa-mir-1-2/Upstream/4909488; hsa-mir-122/Downstream/383289;
Nearest TSS
ENST00000575820/Upstream/63506; ENST00000601719/Downstream/32582;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/166723, chr18-CpG: 42/Downstream/32373
Nearby gene
MAPRE2(-64980) ; ZNF397(+32582) ;
Upstream sequence
accaccacaccacacctattccaaaattgaccacatagttggaagtaaaactctcctcagcaaatgtaaaacaacagaaattataacaaactatctctca
Downstream sequence
gaccacagtgcaatcaaactagaactcaggattaagaatctcactcaaagccactcaactacatggaaactgaacaacctgctcctgaatgactactggg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate