Basic Information
VIS ID
TVIS10014251
Fusion event
HBV-chr18 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
32
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGA| |TCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCG
Host Sequence
Chromosome
chr18
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
37770827/40190863 (Hg38)
End
37770827/40190863 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1-2/Upstream/514084; hsa-mir-122/Downstream/4779219;
Nearest TSS
ENST00000575820/Upstream/124577; ENST00000590220/Downstream/1290205;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/348998, chr18-CpG: 180/Downstream/4488155
Nearby gene
LINC01477(-91630) ; KC6(+1289409) ;
Upstream sequence
ttctcttgtgggcatatagtgctataaatttccctctacacactgctttgaatgcgtcccagagattctggtatgttgtgtctttgttctcattggtttc
Downstream sequence
aaagaacatctttatttctgccttcatttcgttatgtacccagtagtcattcaggagcaggttgttcagtttccatgtagttgagtggctttgagtgagc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate