Basic Information
VIS ID
TVIS10014256
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
11
Orient
+
Integrated sequence
AATTCCACAAC| |CTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCT
Host Sequence
Chromosome
chr2
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
103185998/102569539 (Hg38)
End
103185998/102569539 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA2S ; FRA2A
Nearest miRNA
hsa-mir-1285-2/Upstream/137173; hsa-mir-10b/Downstream/6571951;
Nearest TSS
ENST00000437798/Upstream/66097; ENST00000467657/Downstream/50168;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/213403, chr2-CpG: 110/Downstream/49378
Nearby gene
SLC9A4(-35567) ; SLC9A2(+50168) ;
Upstream sequence
attgtgatgttagggtgtcaattttggatctttcctgctttctcttgtaggcatttagtgctataaatttccctctacacactgctttgaatgcgtccca
Downstream sequence
gagattctggtatgtggtgtctttgttctcgttggtttcaaagaacatctttatttctgccttcatttcgttatgtacccagtagtcattcaggagcagg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate