Basic Information
VIS ID
TVIS10014260
Fusion event
HBV-LINC00486 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2403
Orient
+
Integrated sequence
ACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGG| |TCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCT
Host Sequence
Chromosome
chr2
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
33141618/32916551 (Hg38)
End
33141618/32916551 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
LINC00486
Nearest miRNA
hsa-mir-1301/Upstream/281220; hsa-mir-10b/Downstream/501965;
Nearest TSS
ENST00000437798/Upstream/33750; ENST00000440786/Downstream/10576;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/288348, chr2-CpG: 164/Downstream/29830
Upstream sequence
gggggggggggggggggggggaggggggggggggaggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggg
Downstream sequence
gggggagggggggggggggggggggggggcgggggcggggggggggagggggggggggggggggggggggggggNNNNNNNNNNNNNNNNNNNNNNNNNN
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate