Basic Information
VIS ID
TVIS10014267
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
46
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAG| |GCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCC
Host Sequence
Chromosome
chr3
Cytoband
q27.3
Reference genome
GRCh37/hg19
Start
187145448/187427660 (Hg38)
End
187145448/187427660 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA3C
Nearest miRNA
hsa-let-7g/Upstream/640883; hsa-mir-28/Downstream/1261121;
Nearest TSS
ENST00000440867/Upstream/59328; ENST00000440726/Downstream/21185;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/227692, chr3-CpG: 25/Downstream/242466
Nearby gene
RTP4(-56079) ; SST(+241246) ;
Upstream sequence
cctggctaattttgtatttttagtagacacagagtttctccatgttggtcaggctggtctcgaactcccaacctcaggtgatccgcccacctcagcctcc
Downstream sequence
gttatgtacccagtagtcattcaggagcaggttgttcagtttccatgtagttgagtggctttgagtgagattcttaatcctgagttctagtttgattgca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate