Basic Information
VIS ID
TVIS10014270
Fusion event
HBV-LINC01811 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
56
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTT| |CCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAAC
Host Sequence
Chromosome
chr3
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
34457918/34416426 (Hg38)
End
34457918/34416426 (Hg38)
Orient
-
Location type
Intronic
Target gene
LINC01811
Nearest miRNA
hsa-mir-12127/Upstream/1910037; hsa-let-7g/Downstream/1328050;
Nearest TSS
ENST00000440867/Upstream/213182; ENST00000421492/Downstream/127454;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/617247, chr3-CpG: 86/Downstream/1222591
Nearby gene
PDCD6IP(-546719) ; LOC101928135(+459371) ;
Upstream sequence
CATTGACTCCGTTGGGTGATGGAAGGGACAGATGTGGGATGCAAGGTGAAGAAGAGGAAGGAGCCTAGAACGACCTCCAAGCAACTGTCTTGATTCATTC
Downstream sequence
gttgttcagtttccatgtagttgagtggctttgagtgagattcttaatcctgagttctagtttgattgcactgtggtctgagagatagtttgttataatt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate