Basic Information
VIS ID
TVIS10014272
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
46
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAG| |GCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCC
Host Sequence
Chromosome
chr3
Cytoband
p22.1
Reference genome
GRCh37/hg19
Start
43108938/43067446 (Hg38)
End
43108938/43067446 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12127/Upstream/3929180; hsa-let-7g/Downstream/1046766;
Nearest TSS
ENST00000440867/Upstream/87898; ENST00000457115/Downstream/20033;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/87584, chr3-CpG: 20/Downstream/12483
Nearby gene
GASK1A(-9731) ; POMGNT2(+11783) ;
Upstream sequence
tcataaaagaaatgaaaacactgccaaactatgaaaatcaaataattcagcacgcttaaaattaaccaaaggcacacacacacacacacacatacacaca
Downstream sequence
caatcaaactagaactcaggattaagaatctcactcaaagccactcaactacatggaaactgaacaacctgctcctgaatgactactgggtacataacga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate