Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10014273
Fusion event
HBV-EPHA3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
Polymerase|large S protein|middle S protein|
Start
53
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTA| |TTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTG
Host Sequence
Chromosome
chr3
Cytoband
p11.1
Reference genome
Start
End
89398025/89348875 (Hg38)
Orient
-
Location type
Intronic
Target gene
Nearest miRNA
hsa-let-7g/Upstream/2122598; hsa-mir-12124/Downstream/7011089;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/233918, chr3-CpG: 39/Downstream/4624835
Nearest cancer related gene
EPHA3(TSG, No orient, 0)
Upstream sequence
ACAAAGGCCCTTTTAGGAGGAACTGTCCTACTGGAGTCAAATTTAATCATTGAATCCTATATGGAACTCAGAGTACTGTTCAAAGAGTACTGTTCTTGGG
Downstream sequence
cagtagtcattcaggagcaggttgttcagtttccatgtagttgagtggctttgagtgagattcttaatcctgagttctagtttgattgcactgtggtctg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.