Basic Information
VIS ID
TVIS10014274
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
11
Orient
+
Integrated sequence
AATTCCACAAC| |CTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCT
Host Sequence
Chromosome
chr3
Cytoband
p11.1
Reference genome
GRCh37/hg19
Start
90386070/90336920 (Hg38)
End
90386070/90336920 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/3110643; hsa-mir-12124/Downstream/6023044;
Nearest TSS
ENST00000440867/Upstream/1229244; ENST00000478400/Downstream/3574237;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/1221963, chr3-CpG: 39/Downstream/3636790
Nearby gene
EPHA3(-854786) ;
Nearest cancer related gene
EPHA3(TSG, -854786) ;
Upstream sequence
TCAATTTTGGGGGAAAAAAGTGGAAATAAGTGCTCTAAGGCAAAGGTGAAATAATCTGATAGAGAATTGCAGATTGATATGCTAAAGATAAAGAGATGTA
Downstream sequence
ggacgcattcaaagcagtgtgtagagggaaatttatagcactaaatgcccacaagagaaagcaggaaagatccaaaattgacaccctaacatcacaatta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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