Basic Information
VIS ID
TVIS10014277
Fusion event
HBV-LOC105377356 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
26
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCT| |GCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATC
Host Sequence
Chromosome
chr4
Cytoband
q24
Reference genome
GRCh37/hg19
Start
107495506/106574349 (Hg38)
End
107495506/106574349 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105377356
Nearest miRNA
hsa-mir-12113/Upstream/5243935; hsa-mir-1243/Downstream/2914349;
Nearest TSS
ENST00000502981/Upstream/140725; ENST00000508555/Downstream/461463;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/677737, chr4-CpG: 61/Downstream/461049
Nearby gene
GIMD1(-206914) ; DKK2(+347453) ;
Upstream sequence
aaatggtagaccagtcttcaaattcacatccatttaactctaaagttgcagcttctaatgtcctacgcagcATTTGGCTATTTTAAAACAATTCGAGAGG
Downstream sequence
gtggctttgagtgagattcttaatcctgagttctagtttgattgcactgtggtctgagagatagtttgttataatttctgttcttttacatttgctgagg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate