Basic Information
VIS ID
TVIS10014282
Fusion event
HBV-LINC00504 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
11
Orient
+
Integrated sequence
AATTCCACAAC| |CTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCT
Host Sequence
Chromosome
chr4
Cytoband
p15.33
Reference genome
GRCh37/hg19
Start
14759585/14757961 (Hg38)
End
14759585/14757961 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4D
Target gene
LINC00504
Nearest miRNA
hsa-mir-12113/Upstream/1130004; hsa-mir-12115/Downstream/5770314;
Nearest TSS
ENST00000502981/Upstream/41366; ENST00000503926/Downstream/130206;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1129930, chr4-CpG: 31/Downstream/104923
Nearby gene
LINC01085(-617909) ; CPEB2-DT(+152000) ;
Upstream sequence
aaatgaaattaaagtaaaataaataaaataaaataaaTGTAAAGTGCCTGAACCAACATATGGAACAAAGGTTTACATCCAGCAttgacaaactacagtt
Downstream sequence
ggacgcattcaaagcagtgtgtagagggaaatttatagcactaaatgcctacaagagaaagcaggaaagatccaaaattgacaccctaacatcacaatta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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