FRAS1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10014285
Fusion event
HBV-FRAS1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
26
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCT| |GCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATC
Host Sequence
Chromosome
chr4
Cytoband
q21.21
Reference genome
GRCh37/hg19
Start
79271759/78350605 (Hg38)
End
79271759/78350605 (Hg38)
Orient
+
Location type
Intronic
Target gene
FRAS1
miRNAs that regulate target gene
hsa-mir-124-3p
Nearest miRNA
hsa-mir-12113/Upstream/1774979; hsa-mir-1243/Downstream/4402732;
Nearest TSS
ENST00000502981/Upstream/95359; ENST00000510944/Downstream/68433;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/168498, chr4-CpG: 43/Downstream/201047
Upstream sequence
gggcctcaATCTCAAGGAGGTTCAGCCAGGCCTAGAGCGTGGGCTCATCCACTCGGTGGGCATTTAGCAAGTTATTTTTCTGTGCTTGAGAGAGAGGCTA
Downstream sequence
tcagcaaatgtaaaagaacagaaattataacaaactatctctcagaccacagtgcaatcaaactagaactcaggattaagaatctcactcaaagccactc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate