Basic Information
VIS ID
TVIS10014291
Fusion event
HBV-LOC110806263 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
509
Orient
-
Integrated sequence
TCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCAC| |GGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCC
Host Sequence
Chromosome
chr5
Cytoband
p15.33
Reference genome
GRCh37/hg19
Start
1296678/1296563 (Hg38)
End
1296678/1296563 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC110806263
Nearest miRNA
hsa-mir-4635/Upstream/233589; hsa-mir-10397/Downstream/12747;
Nearest TSS
ENST00000502646/Upstream/1494; ENST00000605200/Downstream/25266;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/708, chr5-CpG: 18/Downstream/38399
Nearby gene
TERT(-1516) ; MIR4457(+12747) ;
Upstream sequence
attattgctgagctccgcatttgccaagtgctttaaatggagagtctttcatgggtcacatttgtggcttcttgggagactcttttcttcagagatgctc
Downstream sequence
AAATGGAAGCAGAAGATTATGCTGGAGTAATTAACACCATGTGCATGGCGAGGAAACGCCTCCCGGCATTCAATGAAGATCGCTGATACCCAGAAGACAC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate