Basic Information
VIS ID
TVIS10014292
Fusion event
HBV-LOC110806263 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2390
Orient
+
Integrated sequence
CAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCC| |TCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGG
Host Sequence
Chromosome
chr5
Cytoband
p15.33
Reference genome
End
1297002/1296887 (Hg38)
Orient
-
Location type
Intronic
Target gene
Nearest miRNA
hsa-mir-4635/Upstream/233913; hsa-mir-10397/Downstream/12423;
Nearest CpG islands
Nearby gene
TERT(-1840) ; MIR4457(+12423) ;
Upstream sequence
cagtggctttgctatgcccctcctctattcctatatcaggatccttgcacacattagtccttctacacagaatgTGTAAGAGGTACTTAAGAATTAAGTA
Downstream sequence
ctttaggaggcagaggcaggtggatcatctgaggtcagaagttcgagaccagcctggccaacatggtgaaccccacccccacccccgtctctactaaaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate