EYA4 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10014295
Fusion event
HBV-EYA4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
11
Orient
+
Integrated sequence
AATTCCACAAC| |CTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCT
Host Sequence
Chromosome
chr6
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
133793412/133472274 (Hg38)
End
133793412/133472274 (Hg38)
Orient
-
Location type
Intronic
Target gene
EYA4
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-203a-3p ; hsa-mir-27b-3p ; hsa-mir-224-5p ; hsa-mir-148b-3p ; hsa-mir-132-3p ; hsa-mir-128-3p ; hsa-mir-122-5p ; hsa-mir-181a-5p
Nearest miRNA
hsa-mir-10398/Upstream/1357011; hsa-mir-1202/Downstream/1507064;
Nearest TSS
ENST00000381078/Upstream/9561; ENST00000606160/Downstream/39454;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/229507, chr6-CpG: 43/Downstream/191709
Nearest cancer related gene
EYA4(TSG, No orient, 0)
Upstream sequence
CGCGTCAGTCTCAGGGACTCCATCTCTGGAGCCTTTCCCGGGCCTGCCTCTCCCGGTCCTTCCCTGTAGAAACGGTCTCTCCTACCCCAGACACTCATTC
Downstream sequence
gagattctggtatgtggtgtctttgttctcgttggtttcgaagaacatctttatttctgccttcatttcgttatgtacccagtagtcattcaggagcagg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate