Basic Information
VIS ID
TVIS10014296
Fusion event
HBV-LOC105378071 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
11
Orient
+
Integrated sequence
AATTCCACAAC| |CTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCT
Host Sequence
Chromosome
chr6
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
156649297/156328163 (Hg38)
End
156649297/156328163 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105378071
Nearest miRNA
hsa-mir-10398/Upstream/381284; hsa-mir-1913/Downstream/451515;
Nearest TSS
ENST00000381078/Upstream/872260; ENST00000637910/Downstream/170803;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/1013415, chr6-CpG: 41/Downstream/68774
Nearby gene
NOX3(-872260) ; ARID1B(+449767) ;
Upstream sequence
TCCCTCTTGCACAGAGACTCTTTTTCAAGCCACGTAGTTGCCTGAACCTTCATTTCTGATGCAGGTGTGCACAGTGGTAGTCATAGAGGAGGAAACTGTG
Downstream sequence
gagattctggtatgtggtgtctttgttctcgttggtttcaaagaacatctttatttctgccttcatttcgttatgtacccagtagtcattcaggagcagg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate