Basic Information
VIS ID
TVIS10014298
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
Polymerase|large S protein|middle S protein|
Start
11
Orient
+
Integrated sequence
AATTCCACAAC| |CTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCT
Host Sequence
Chromosome
chr6
Cytoband
q14.1
Reference genome
End
81511029/80801312 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/2262003; hsa-mir-1202/Downstream/9511430;
Nearby gene
BCKDHB(-455042) ; TENT5A(+944418) ;
Nearest cancer related gene
BCKDHB(OG, -455042) ;
Upstream sequence
TGGGAGGCTGGGTCCAATGCATGGGCCACGGGCACCCCCACTGATACCACCCGCACAGGGTCTGGGTAAACCTGAGGTCAAGAGGGGACAGGCCCGTTAA
Downstream sequence
ggatgccttcaaagcagtgtgtagagggaaatttatagcactaaatgcccacaagagaaagcaggaaagatccaaaattgacaccctaacatcacaatta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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