COL14A1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10014299
Fusion event
HBV-COL14A1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
30
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAA| |GATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCT
Host Sequence
Chromosome
chr8
Cytoband
q24.12
Reference genome
GRCh37/hg19
Start
121363275/120351036 (Hg38)
End
121363275/120351036 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8C ; FRA8E
Target gene
COL14A1
miRNAs that regulate target gene
hsa-mir-324-5p ; hsa-mir-210-5p ; hsa-mir-3189-5p ; hsa-mir-4758-3p ; hsa-mir-5699-5p ; hsa-mir-324-3p ; hsa-mir-1913 ; hsa-mir-6752-3p ; hsa-mir-7108-3p ; hsa-mir-6810-3p ; hsa-mir-6801-3p ; hsa-mir-548an
Nearest miRNA
hsa-mir-12123/Upstream/1025771; hsa-mir-10400/Downstream/2864752;
Nearest TSS
ENST00000518652/Upstream/5590; ENST00000456899/Downstream/63076;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/225497, chr8-CpG: 24/Downstream/94077
Upstream sequence
gagggatatgctaattagcgtgatttatacatatattgcaatatatacatgtatcgaaacatcacattgtgcctcataaatatatataattatcatcaac
Downstream sequence
ctctcagaccacagtgcaatcaaactagaactcaggattaagaatctcactcaaagccactcaactacatggaaactgaacaacctgctcctgaatgact
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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