Basic Information
VIS ID
TVIS10014302
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
53
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTA| |TTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTG
Host Sequence
Chromosome
chrX
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
108359206/109115976 (Hg38)
End
108359206/109115976 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7f-2/Upstream/2476080; hsa-mir-105-1/Downstream/939353;
Nearest TSS
ENST00000429181/Upstream/379436; ENST00000372107/Downstream/366096;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/379061, chrX-CpG: 30/Downstream/420849
Nearby gene
LOC101928358(-377073) ; GUCY2F(+256929) ;
Upstream sequence
gcttcaagataaatgatgatatcttgggagaaccagattttagctgatgaaaaaatagtaatgaaaattagaaaCTAATTTTGTAAGAGGGTGAGAAAAA
Downstream sequence
gaccacagtgcaatcaaactagaactcaggattaagaatctcactcaaagccactcaactacatggaaactgaacaacctgctcctgaatgactactggg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate