Basic Information
VIS ID
TVIS10014303
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
55
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATT| |TCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAA
Host Sequence
Chromosome
chrX
Cytoband
q23
Reference genome
GRCh37/hg19
Start
110835215/111591987 (Hg38)
End
110835215/111591987 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7f-2/Upstream/1509769; hsa-mir-105-1/Downstream/1188731;
Nearest TSS
ENST00000429181/Upstream/80207; ENST00000622986/Downstream/73824;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/495536, chrX-CpG: 22/Downstream/32256
Nearby gene
SERTM2(-69588) ; ALG13(+89131) ;
Upstream sequence
AATCCACTGGCTTAAATCCATACTAAACTCTAAAGAGCTGATATAAAATTTATTTCTGAGGATGAACATACTGGATTCCTAAGAGGAGAAATGGGATAGA
Downstream sequence
gtttccatgtagttgagtggctttgagtgagattcttaatcctgagttctagtttgattgcactgtggtctgagagatagtttgttataatttctgttct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate