Basic Information
VIS ID
TVIS10014309
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
41
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGT| |GAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGG
Host Sequence
Chromosome
chrX
Cytoband
q12
Reference genome
GRCh37/hg19
Start
66147965/66928123 (Hg38)
End
66147965/66928123 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7f-2/Upstream/909144; hsa-mir-105-1/Downstream/3094734;
Nearest TSS
ENST00000429181/Upstream/288825; ENST00000513847/Downstream/615909;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/1105661, chrX-CpG: 27/Downstream/615840
Nearby gene
EDA2R(-288825) ; AR(+615909) ;
Nearest cancer related gene
EDA2R(TSG, -288825) ; AR(OG, +615909) ;
Upstream sequence
GAGCAATGAGGATGATTGATTGATATGGGGGAAGGGGTAGTTAGGAGTGTTTTCACTGTCTTTCTGGATTATAGTTTTTTACTCATATGCATGTATTACC
Downstream sequence
aggagcaggttgttcagtttccatgtagttgagtggctttgagtgagattcttaatcctgagttctagtttgattgcactgtggtctgagagatagtttg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate