Basic Information
VIS ID
TVIS10014314
Fusion event
HBV-LOC107985594 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1890
Orient
+
Integrated sequence
ATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGG| |TGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATC
Host Sequence
Chromosome
chr1
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
145388254/146046744 (Hg38)
End
145388254/146046744 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1F
Target gene
LOC107985594
Nearest miRNA
hsa-mir-101-1/Upstream/196099; hsa-mir-1182/Downstream/2287735;
Nearest TSS
ENST00000473358/Upstream/9998; ENST00000612371/Downstream/5822;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/27143, chr1-CpG: 30/Downstream/2616
Nearby gene
NBPF10(-19570) ; HJV(+24937) ;
Upstream sequence
CACTGTTCCTGTGACAGAGAGCCCAGGCTTCAGCTGCTGAAGAAGAACTCAGACCTAACCCTCCAGGGCGGGACCTTTAATTTGGCACAGAGTTGGTCCT
Downstream sequence
TAGCCAAATAAAAATTGAAAAGGGGAGATTTTAAATTTTCATCTAATTAAGACTTTATATAATGGATCTTTTTCTTATTGTGGCAACAAGAGGAGAGATT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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