Basic Information
VIS ID
TVIS10014317
Fusion event
HBV-LINC01362 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1828
Orient
+
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr1
Cytoband
p31.1
Reference genome
GRCh37/hg19
Start
83468739/83003056 (Hg38)
End
83468739/83003056 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1L
Target gene
LINC01362
Nearest miRNA
hsa-mir-101-1/Upstream/5942854; hsa-mir-11399/Downstream/2130738;
Nearest TSS
ENST00000473358/Upstream/16848; ENST00000446227/Downstream/442911;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1199693, chr1-CpG: 50/Downstream/857528
Nearby gene
LPHN2(-1010632) ; MIR548AP(+790859) ;
Upstream sequence
CTTAAACTAGCTTGTTTCTTATAAAGCATGGAGAAACTTCTGAAATATAAAATATAGGAAGCACAAATATAATGGTAACACACAAGAAGAAGAGGGTAGG
Downstream sequence
TGGTTGTGGATGGAGGGGATAAAAGGCCATGCCATTTAGGAATTCTTACAGAAGCTTTTTAACTACACAGGCCAGAGAAATGAAGTATTTTATTTTGTCG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate