GRK5 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10014319
Fusion event
HBV-GRK5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1828
Orient
+
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr10
Cytoband
q26.11
Reference genome
GRCh37/hg19
Start
120968966/119209454 (Hg38)
End
120968966/119209454 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10F ; FRA10A ; FRA10B
Target gene
GRK5
miRNAs that regulate target gene
hsa-mir-941 ; hsa-mir-4758-5p ; hsa-mir-1238-5p ; hsa-mir-4481 ; hsa-mir-4745-5p ; hsa-mir-570-3p
Nearest miRNA
hsa-mir-107/Upstream/2041680; hsa-mir-202/Downstream/168518;
Nearest TSS
ENST00000439456/Upstream/1865; ENST00000369108/Downstream/126503;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/1343, chr10-CpG: 181/Downstream/332512
Upstream sequence
ACCCCAGCAGAGTTTAAAATATTCAGGTTAGTCTCCCTCCCATTGCTTAGCTTTGGTGGGAATAAATTTTTAGGAGAGGCTTGTTACTTGGTGACTTCAG
Downstream sequence
GTTCTAAGGCCTGAGCTGTGTGTGTGTGTGTGGtttttttttttttttttttttttttttCCTAACCTGACATTTTTAGTGGACAGGATCTAGGTGGGTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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