Basic Information
VIS ID
TVIS10014325
Fusion event
HBV-chr10 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2119
Orient
+
Integrated sequence
GAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGG| |GTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTC
Host Sequence
Chromosome
chr10
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
82748414/80988658 (Hg38)
End
82748414/80988658 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA10D
Nearest miRNA
hsa-mir-1265/Upstream/5436105; hsa-mir-107/Downstream/5276036;
Nearest TSS
ENST00000439456/Upstream/338861; ENST00000404547/Downstream/886656;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/452222, chr10-CpG: 149/Downstream/885635
Nearby gene
SH2D4B(-342098) ; NRG3(+886656) ;
Upstream sequence
CTCTCAGTATTTAGCTTAGAATTTTTAAAAGGAAAGGCCTCACATCCCAGAAATGGGTATAATTATGTCCCACTCTGTTGTGTGGCTTAGCAGAGACAAT
Downstream sequence
ATCCCCTACCTCCCGACCAAGGGCGAGAGTAGGAGGTAAGTTAGTCTGCAGCAGGACATAAAGCTGGAACCTATCTAGGAGGTGAAGGAAGAGAGGCTAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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