PGR _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10014326
Fusion event
HBV-PGR integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1828
Orient
+
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr11
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
100993990/101123259 (Hg38)
End
100993990/101123259 (Hg38)
Orient
+
Location type
Intronic
Target gene
PGR
miRNAs that regulate target gene
hsa-mir-126-3p ; hsa-mir-181a-5p ; hsa-mir-378a-3p
Nearest miRNA
hsa-mir-10392/Upstream/4781733; hsa-let-7a-2/Downstream/396561;
Nearest TSS
ENST00000527297/Upstream/59234; ENST00000532529/Downstream/3829;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/435589, chr11-CpG: 170/Downstream/4040
Nearest cancer related gene
PGR(TSG, No orient, 0)
Upstream sequence
gtaaagtgggagtaataataataataccaacattataacaactaaataagttaagacctgcaaagcactgaaatagtcactggcacagagaaagcatttt
Downstream sequence
ataaTGCCATCATTTTCATTCTCATCCTTGGCAACATTAGTATCCATATTGTTGCCTGTTTACTTTAAACTTCTGGCCATATTGGCATCCACACACAGCG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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