ANO4 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10014333
Fusion event
HBV-ANO4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1828
Orient
+
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr12
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
101233946/100840168 (Hg38)
End
101233946/100840168 (Hg38)
Orient
-
Location type
Intronic
Target gene
ANO4
miRNAs that regulate target gene
hsa-mir-378c
Nearest miRNA
hsa-let-7i/Upstream/650219; hsa-mir-1178/Downstream/3090257;
Nearest TSS
ENST00000382841/Upstream/45210; ENST00000549234/Downstream/19094;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/122324, chr12-CpG: 62/Downstream/369441
Upstream sequence
TGAGTGGTGTGTTCAGTGAAATTTTCTGACATGAAAAAGAAGTCCTTAAACCAAAaataataataataataataacaataaAGGGACCACTGTCTTAGAA
Downstream sequence
AACATTAGTTACCCGTTCTCTTTCCTTCTCAAGGAGGAATGACTTCAGTGCAATTAACAATCCGTGTCTTTGTGTCCCAGTTTGATCTTGCCCAGTTTGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate