Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10014336
Fusion event
HBV-CEP290 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|
Start
2155
Orient
+
Integrated sequence
CATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAG| |TAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTA
Host Sequence
Chromosome
chr12
Cytoband
q21.32
Reference genome
Start
End
88479722/88085945 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
Target gene
Nearest miRNA
hsa-let-7i/Upstream/1340796; hsa-mir-1178/Downstream/6475844;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/50116, chr12-CpG: 34/Downstream/56013
Upstream sequence
AATAGTGAATTCAAATTAACTATATCTGCTGTTCATTATTGGCTATTAGAAACATTATAGGAGAATAGAAAAATAGTGAAATTAGCAATAGATTCATCAT
Downstream sequence
TCTATGCATTGCCCTCATAAAGAAATATTATTTAGAAAGCCCCCCAAACATACCAAATAATACACTAATCAAAATGCAAATTCTTCTAATTACCTCTTCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.