DIAPH3 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10014339
Fusion event
HBV-DIAPH3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
735
Orient
-
Integrated sequence
ATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCA| |GTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATTT
Host Sequence
Chromosome
chr13
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
60657671/60083537 (Hg38)
End
60657671/60083537 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA13B ; FRA13C
Target gene
DIAPH3
miRNAs that regulate target gene
hsa-mir-155-5p
Nearest miRNA
hsa-mir-1297/Upstream/4908989; hsa-mir-1267/Downstream/1116261;
Nearest TSS
ENST00000623511/Upstream/70231; ENST00000428656/Downstream/61161;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/2448741, chr13-CpG: 52/Downstream/79989
Upstream sequence
aaagaatataatacttcttatgatcttggtaaagagatgaaacctgagtctgatcatgcctctagatctagctgtctctgtgcaggaaatacagaggata
Downstream sequence
ggaaaacacgttaactttaccacaaatacacacatcagcaaaattcagaatgtCCTGGATAAAATAACTGAAGATTAAACAAGACATAGAGATAATCCAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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