Basic Information
VIS ID
TVIS10014346
Fusion event
HBV-chr15 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
71
Orient
-
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTC| |CAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACA
Host Sequence
Chromosome
chr15
Cytoband
q15.2
Reference genome
GRCh37/hg19
Start
43416301/43124103 (Hg38)
End
43416301/43124103 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1233-1/Upstream/924437; hsa-mir-10393/Downstream/669556;
Nearest TSS
ENST00000557528/Upstream/824; ENST00000570109/Downstream/9041;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/202700, chr15-CpG: 34/Downstream/9601
Nearby gene
UBR1(-18015) ; TMEM62(+9421) ;
Upstream sequence
ttggcctcccaagtagctgggattacaggcCTTTTAAGATTAAAGACTGTTTTTCATTTTGCTTAATCTTTGGACTGCTGGTAATGTAGATATTGAGAAC
Downstream sequence
CCTTGAGCATGACTTTAAAATGGCAGCAACTTGAATCTTGAAGTATTGGAACACCGGTGTAAACATGAAACACCTTTACACCCAtgtatggatgtgccat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate