VISDB Viral Integration Site DataBase

VIS ID

TVIS10014351

Fusion event

HBV-IGDCC4 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|

Start

1862

Orient

+

Integrated sequence

AAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTAC| |TGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCT

Chromosome

chr15

Cytoband

q22.31

Reference genome

Start

End

65674509/65382171 (Hg38)

Orient

+

Location type

UTR3

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-215-5p ; hsa-mir-196a-5p ; hsa-mir-192-5p ; hsa-let-7d-5p ; hsa-mir-423-5p ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-570-3p ; hsa-mir-6859-5p ; hsa-mir-3125 ; hsa-mir-3916 ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-651-3p ; hsa-mir-6748-5p ; hsa-mir-513a-5p ; hsa-mir-6766-5p ; hsa-mir-6756-5p ; hsa-mir-7109-3p ; hsa-mir-1303 ; hsa-mir-3678-3p ; hsa-mir-2467-3p ; hsa-mir-3166 ; hsa-mir-202-3p ; hsa-mir-6770-5p ; hsa-mir-3123 ; hsa-mir-3925-5p ; hsa-let-7g-5p ; hsa-mir-98-5p ; hsa-mir-4500 ; hsa-mir-4458 ; hsa-let-7i-5p ; hsa-let-7f-5p ; hsa-let-7a-5p ; hsa-let-7c-5p ; hsa-let-7e-5p ; hsa-let-7b-5p ; hsa-mir-196b-5p ; hsa-mir-1273e ; hsa-mir-1288-5p

Nearest miRNA

hsa-mir-10393/Upstream/619656; hsa-mir-11181/Downstream/337075;

Nearest TSS

Nearest CpG islands

None/Target, chr15-CpG: 55/Upstream/3892, chr15-CpG: 68/Downstream/13530

Upstream sequence

AGGGCAGTTTTTTTTTCTTCTTTAAAAAAAAAAAATCAAACCAGCAAAATAAAATGAGGCTTTTGACCTTCAGAGCAATGATGAAACATACACAGTGGTG

Downstream sequence

TTAGCCACAGCAGCGCTGAATGCTACAGAAATACTACAAGTGACAATTCTGTCTTTAACGAGATACAAAACCAACATTAATAATCTTTAGTGTTATCATA