Basic Information
VIS ID
TVIS10014359
Fusion event
HBV-chr16 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2222
Orient
+
Integrated sequence
TTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTG| |TCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTA
Host Sequence
Chromosome
chr16
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
28673094/28661773 (Hg38)
End
28673094/28661773 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/270722; hsa-mir-11401/Downstream/62479;
Nearest TSS
ENST00000527434/Upstream/9539; ENST00000569690/Downstream/26785;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/38063, chr16-CpG: 59/Downstream/49483
Nearby gene
SULT1A1(-38187) ; EIF3C(+49688) ;
Upstream sequence
agatcgcaccactgcactccagccgggatgacagagcaagaccctgtctcaaaaaaaagaaaaaggaacaaacaaCAGCAACAACAAAAAAACCTCTGTG
Downstream sequence
TCAATCACAGCCTTCAAGCTAGGGGAGAGGCGGCcgaattctgccctctgctaactaactatagctttgtggaaatgggcgagtggcatgcccctgtgag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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