Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10014364
Fusion event
HBV-WWOX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|
Start
1912
Orient
+
Integrated sequence
ACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCG| |ACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCT
Host Sequence
Chromosome
chr16
Cytoband
q23.1
Reference genome
Start
End
78230741/78196844 (Hg38)
Orient
+
Location type
Intronic
Target gene
Nearest miRNA
hsa-mir-1225/Upstream/1327825; hsa-mir-11401/Downstream/3188174;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/96675, chr16-CpG: 44/Downstream/1392750
Nearest cancer related gene
WWOX(TSG, No orient, 0)
Upstream sequence
CCTATTTTGCTTCTGCAATGAATTTCATTGCCTGCATTGTAAAATCAGCAGGTAGCAAAGTTTCTGCTAATGATTTAATGTACTCTCTGATCATTTTGGA
Downstream sequence
CAAAAGTCATGGTAAGATCCACAAGGCAATTTTATCATCCCCACTGACTACTGCCTGGTTTAAGCATTTTAAGTGAAGACAAAACATGATTCTCATCTCC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.