Basic Information
VIS ID
TVIS10014365
Fusion event
HBV-chr16 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1824
Orient
-
Integrated sequence
TTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAG
Host Sequence
Chromosome
chr16
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
82385873/82352268 (Hg38)
End
82385873/82352268 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/740860; hsa-mir-11401/Downstream/336663;
Nearest TSS
ENST00000527434/Upstream/181972; ENST00000569455/Downstream/158628;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/181471, chr16-CpG: 100/Downstream/274778
Nearby gene
MPHOSPH6(-182044) ; CDH13(+274526) ;
Nearest cancer related gene
CDH13(TSG, +274526) ;
Upstream sequence
aggctccacttctaattctcttactatttctaccacatctgcggttctttcctccactgaagtcttaaaccttttaacatcatctatgagggttggaatc
Downstream sequence
aactttctttctttctttctttctttctttctttctttcttgctttcttgctttcttgctttcttgctttcttgctttcttgctttcttgctttcttgct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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