Basic Information
VIS ID
TVIS10014369
Fusion event
HBV-chr17 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1813
Orient
+
Integrated sequence
AGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCA| |CCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGA
Host Sequence
Chromosome
chr17
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
5490907/5587587 (Hg38)
End
5490907/5587587 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1253/Upstream/617437; hsa-mir-10226/Downstream/1067853;
Nearest TSS
ENST00000595228/Upstream/3056; ENST00000563763/Downstream/31837;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/86305, chr17-CpG: 112/Downstream/482408
Nearby gene
NLRP1(-3075) ; LOC339166(+184647) ;
Upstream sequence
tgtatccgctatgcctaaatcagtgcctggcccacaatgtcagcacaatcaataCCACAGACATTGAATGTCTTTTGAACGCTTTCCTTTAATGCTTTCC
Downstream sequence
TTCTTATCCTTCCAAACAGCTACTCACTCTGGCCACTAGATGGCACTCAAGTACTTTCTGAGAATTGAAGCAGCCTCATGGGTTTGGTGGAGAGGACCCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate