VISDB Viral Integration Site DataBase

VIS ID

TVIS10014370

Fusion event

HBV-SPIRE1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1785

Orient

-

Integrated sequence

CAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTG| |TAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCC

Chromosome

chr18

Cytoband

p11.21

Reference genome

Start

End

12451987/12451988 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-151a-5p ; hsa-mir-186-5p ; hsa-mir-101-3p ; hsa-mir-769-5p ; hsa-mir-484 ; hsa-mir-99a-5p ; hsa-mir-218-5p ; hsa-mir-215-3p ; hsa-mir-6777-3p ; hsa-mir-3976 ; hsa-mir-369-3p ; hsa-mir-3123 ; hsa-mir-3925-5p ; hsa-mir-510-5p ; hsa-mir-4662a-3p ; hsa-mir-374c-5p ; hsa-mir-655-3p ; hsa-mir-181c-5p ; hsa-mir-181a-5p ; hsa-mir-181d-5p ; hsa-mir-4262 ; hsa-mir-181b-5p

Nearest miRNA

hsa-mir-3976/Upstream/797047; hsa-mir-1-2/Downstream/1007959;

Nearest TSS

Nearest CpG islands

None/Target, chr18-CpG: 67/Upstream/17501, chr18-CpG: 198/Downstream/205057

Upstream sequence

TAAACAGATTCCTTTCAAAACTAGACAAGGAGGAAAGGATGAGACTGTTACATTCCAATTTTCAACTCCATTGAAAACAAGGTCAGTTTTAAAGATGACT

Downstream sequence

CTTACAGGACACAGTAAAACAGTTATTTCTAAAGTAGAAAAAAATATAAACTCTGTGATGAAAGTATCTTTCAAGTAGCTAGCCATTATTCCTTGAAAAG