VISDB Viral Integration Site DataBase

VIS ID

TVIS10014371

Fusion event

HBV-SPIRE1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2192

Orient

+

Integrated sequence

AACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTT| |CAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCA

Chromosome

chr18

Cytoband

p11.21

Reference genome

Start

End

12452039/12452040 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-151a-5p ; hsa-mir-186-5p ; hsa-mir-101-3p ; hsa-mir-769-5p ; hsa-mir-484 ; hsa-mir-99a-5p ; hsa-mir-218-5p ; hsa-mir-215-3p ; hsa-mir-6777-3p ; hsa-mir-3976 ; hsa-mir-369-3p ; hsa-mir-3123 ; hsa-mir-3925-5p ; hsa-mir-510-5p ; hsa-mir-4662a-3p ; hsa-mir-374c-5p ; hsa-mir-655-3p ; hsa-mir-181c-5p ; hsa-mir-181a-5p ; hsa-mir-181d-5p ; hsa-mir-4262 ; hsa-mir-181b-5p

Nearest miRNA

hsa-mir-3976/Upstream/797099; hsa-mir-1-2/Downstream/1007907;

Nearest TSS

Nearest CpG islands

None/Target, chr18-CpG: 67/Upstream/17553, chr18-CpG: 198/Downstream/205005

Upstream sequence

TTCCAATTTTCAACTCCATTGAAAACAAGGTCAGTTTTAAAGATGACTCTTACAGGACACAGTAAAACAGTTATTTCTAAAGTAGAAAAAAATATAAACT

Downstream sequence

CTGTGATGAAAGTATCTTTCAAGTAGCTAGCCATTATTCCTTGAAAAGTTACCTTTGGGGAAGTTTTGGAGATTTGTGTGTAAAACTGTATTAAAACCAA